河南省医学科技攻关计划项目201403254;郑州市科技发展计划项目20150171,20150172;河南省医学科学院联合共建项目2018020653,2018020689,2018020692,2018020696;Henan Provincial Key Science and Technology Research Project201403254;Science and Technology Development Program of Zhengzhou20150171, 20150172;Joint Construction Project of Henan Academy of Medical Sciences2018020653, 2018020689, 2018020692, 2018020696