Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
Sepsis is a complex syndrome caused by multi-ple pathogens and involves multiple organ failure, par-ticularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. Liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has anti-hypertensive and antiarrhythmic pharmacological ef-fects. It can exert anti-carcinogenic activity by regulat-ing cell, inflammation, and apoptosis signaling path-ways (Manogaran et al., 2019). However, its protec-tive effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxi-dative stress, and apoptosis.
stress、tissue、mouse、model、attenuates、inflammation、liensinine、lps-induced、oxidative、sepsis
24
TM73;TV122.1;H313
2023-02-16（万方平台首次上网日期，不代表论文的发表时间）
共7页
185-190,后插1-后插3
