国家自然科学基金青年科学基金项目71403229;厦门市卫生和计划生育委员会委托项目XDHT2015591A;福建省自然科学基金面上项目2017J01133;National Natural Science Foundation of China71403229;Commissioned Project of Xiamen Health and Family Planning CommissionXDHT2015591A;Natural Science Foundation of Fujian Province2017J01133