国家自然科学基金青年基金项目81501783;海南省自然科学基金青年基金项目818QN326;海南省重点研发计划科技合作方向项目ZDYF2017163;海南省医药卫生科研项目1602320116A2001Fund programs: National Natural Science Foundation of China81501783;Hainan Natural Science Foundation Youth Fund Project818QN326;Hainan Key Research and Development Plan, Scientific and Technological Cooperation ProgramZDYF2017163;Hainan Medical and Health Research Project1602320116A2001