国家自然科学基金82070026;广东省基础与应用基础研究基金自然科学基金2019A1515010622;广州市临床特色技术项目2019TS24;广东省钟南山医学基金ZNSA-2020013,ZNSA-2020003;National Natural Science Foundation of China82070026;Guangdong Provincial Foundation for Basic and Applied Basic Research Natural Science Foundation2019A1515010622;Guangzhou Clinical Characteristic Technology Project Foundation2019TS24;Zhongnanshan Medical Foundation of Guangdong ProvinceZNSA-2020013, ZNSA-2020003