国家自然科学基金81800287;河南省中青年卫生健康科技创新人才项目YXKC2020047;河南省医学科技攻关计划省部共建项目SB201902031;National Natural Science Foundation of China81800287;Henan Province Young and Middle-aged Health Science and Technology Innovation Talent ProjectYXKC2020047;The Medical Science and Technology Project of Henan Province and Ministry Co-constructionSB201902031