国家自然科学基金9184910151,81870552,81400790,81460203,31760299,81571385,91849132,81872096;国家重点研发计划2018YFC2000400;广西自然科学基金2014GXNSFDA118028、2018GXNSFAA138156、桂科自0991198;广西壮族自治区卫生和计划生育委员会自筹经费科研课题Z20170162;北京医院创新项目BJ-2018-139;中国医学科学院研究院基金2018RC330003;National Natural Science Foundation of China9184910151, 81870552, 81400790, 81460203, 31760299, 81571385, 91849132, 81872096;National Key Research and Development Program of China2018YFC2000400;Guangxi Natural Science Foundation2014GXNSFDA118028, 2018GXNSFAA138156, guikezi0991198;Self-funded Scientific Research Project of the Health and Family Planning Commission of Guangxi Zhuang Autonomous RegionZ20170162;Beijing Hospital Nova ProjectBJ-2018-139;Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences2018RC330003