国家自然科学基金81790653,81871345;江苏省医学重点人才计划ZDRCA2016093;江苏省自然科学基金社会发展项目BE2016751;国家重点研发计划2018YFA0701703;National Nature Science Foundation of China81790653, 81871345;Key Talent Project in Jiangsu ProvinceZDRCA2016093;Natural Scientific Foundation-Social DevelopmentBE2016751;National Key Technology R&D Program of the Ministry of Science and Technology2018YFA0701703