国家自然科学基金81572217;浙江省自然科学基金LY19H060002,LY18H060007;浙江省医药卫生科技计划2020391275;宁波市自然科学基金202003N4299;National Natural Science Foundation of China81572217;Natural Science Foundation of Zhejiang ProvinceLY19H060002, LY18H060007;Medical and Health Science and Technology Program of Zhejiang Province2020391275;Ningbo Natural Science Foundation202003N4299