国家自然科学基金81700601,81870504;国家科技重大专项项目2020ZX09201-009;上海市徐汇区卫生健康委员会科研项目SHXH201605,SHXH201648;National Natural Science Foundation of China81700601, 81870504;National Science and Technology Major Project of China2020ZX09201-009;Scientific Research Project of Health Commission of Shanghai Xuhui DistrictSHXH201605, SHXH201648