国家重点研发计划2017YFC0110602;国家自然科学基金81301553、81641171;山东省重点研发计划项目2018GSF118064;山东省医药卫生科技发展计划项目2017WS169;National Key R&D Program of China2017YFC0110602;National Natural Science Foundation of China81301553, 81641171;Key R&D Program of Shandong Province2018GSF118064;Project of Medical and Health Technology Development Program of Shandong Province2017WS169