国家自然科学基金81970495;公益性行业科研专项201002020;中国医学科学院医学与健康科技创新工程基金2016-I2M-3-001、2019-I2M-2-007;National Nature Science Foundation of China81970495;Health Research & Special Projects Grant of China201002020;CAMS Innovation Fund for Medical Sciences2016-I2M-3-001, 2019-I2M-2-007