国家自然科学基金81671089;浙江省自然科学基金LY19H090004、LQ19H090004;浙江省医药卫生科技计划项目2020KY266;宁波市自然科学基金2018A610304、2018A610216;National Natural Science Foundation of China81671089;Zhejiang Provincial Natural Science Foundation of ChinaLY19H090004,LQ19H090004;Medical Scientific Research Foundation of Zhejiang Province2020KY266;Ningbo Natural Science Foundation of China2018A610304,2018A610216