国家自然科学基金资助项目81570440;国家自然科学基金资助项目81700408;上海市卫计委科研项目20164Y0096;上海市科学技术委员会科研计划项目16411966500National Natural Science Foundation of China81570440;National Natural Science Foundation of China81700408;Shanghai Municipal Commission of Health Research project20164Y0096;the Guiding Project of Western medicine from the Science and Technology Commission of Shanghai Municipality16411966500