国家自然科学基金面上项目81671760,81873910;黑龙江省卫生计生委课题CR201807;黑龙江省医学科学院科研转化专项基金CR201807National Natural Science Foundation of China81671760,81873910;Scientific Research Transformation Special Fund of Heilongjiang Academy of Medical SciencesCR201807;Scientific Research Project of Health and Family Planning Commission of Heilongjiang ProvinceCR201807