国家卫生和计划生育委员会卫生公益性行业科研专项201202025、201502009;国家科技部科技支撑计划2015BAI12B01、2015BAI12B02;高等学校学科创新引智计划项目B16005Research Special Fund for Public Welfare Industry of Health 201202025,201502009 from the National Health and Family Planning Commission of China;National Key Technology R&D Program 2015BAI12B01,2015BAI12B02 from the Ministry of Science and Technology of China;the 111 ProjectB16005