国家科技重大专项2013ZX03005013;国家自然科学基金面上项目81672139, 81371942;卫生部公益性行业科研专项201402016;辽宁省教育厅科学研究一般项目L2015021National Science and Technology Major Project2013ZX03005013;National Natural Science Foundation of China81672139,81371942;Public Welfare Special Research Project of Ministry of Public Health201402016;Scientific Research Foundation of Liaoning Province Education DepartmentL2015021