National Natural Science Foundation of China81470228,81670026,81500023;Medical Scientific Research Foundation of Guangdong ProvinceA2015386;Natural Science Foundation of Guangdong Province 2014A030310325国家自然科学基金81470228,81670026,81500023;广东省医学科研基金A2015386;广东省自然科学基金2014A030310325