国家自然科学基金81170472、81400088;天津市应用基础与前沿技术研究计划14JCYBJC27200、09JCYBJC11200;天津市抗癌重大专项攻关计划12ZCDZSY17900National Natural Science Foundation of China 81170472, 81400088;Application Basic and Advanced Technology Research Program of Tianjin 14JCYBJC27200, 09JCYBJC11200;Tianjin Major Anticancer Research Program12ZCDZSY17900