国家自然科学基金81800861;天津市重点研发计划科技支撑重点项目19YFZCSY00990;天津市卫生健康科技基金面上项目TJWJ2021MS041;National Natural Science Foundation of China81800861;Science and Technology Support Key Program Affiliated to the Tianjin Key Research and Development Plan19YFZCSY00990;General Project of Tianjin Health Science and Technology FundTJWJ2021MS041