广东省基础与应用基础研究基金2019A1515111003;深圳市医疗卫生三名工程SZSM201811096;深圳市战略性新兴产业发展专项资金(“创新链+产业链”融合专项)ZDYBH201900000007;院士青年英才培育基金YS-2019-008;Guangdong Basic and Applied Basic Research Foundation2019A1515111003;the Fund of "Sanming" Project of Medicine in ShenzhenSZSM201811096;the Shenzhen Strategic Emerging Industry Development Special FundZDYBH201900000007;Young Talent Program of the Academician Fund, Fuwai Hospital Chinese Academy of Medical Sciences, ShenzhenYS-2019-008