国家重大科技专项2014ZX10001002-001-003;政府间国际科技创新合作重点专项2017YE0103800;山东省医药卫生科技发展计划2013WS0160;National Science and Technology Major Project of China2014ZX10001002-001-003;Key Project of International Science and Technology Innovation2017YE0103800;Development of Medical Science and Technology Project of Shandong Province2013WS0160