广东省医学科学技术研究基金C2018036;广州市科技计划201707010451;广州市医学重点项目20181A031002;广东省自然基金2019A1515011407;Guangdong Medical Science and Technology Research FundingC2018036;Guangzhou Science and Technology Planning Project201707010451;Guangzhou Key Medical project20181A031002;Guangdong Natural Funding Project2019A1515011407