国家科技重大专项2013ZX10004203、2012ZX10004215;河南省科技攻关课题152102310133;河南省医学科技攻关计划项目201602306 National Science and Technology Major Project2013ZX10004203, 2012ZX10004215;Henan Province Science and Technology Research Project152102310133;Henan Province Medical Science and Technology Research Project201602306