Ministry of Health's Special Funds for Scientific Research on Public Casuses201402016;National Natural Science Foundation of China81572122;Shanghai Municipal Commission of Health and Family Planning Research Project 20144Y0256卫生部行业基金公益项目201402016;国家自然科学基金面上项目81572122;上海市卫生和计划生育委员会基金项目20144Y0256