国家重点研发计划2020YFC2006100;河南省重点研发与推广专项科技攻关项目182102310179;河南省医学科技攻关项目2018020237,2018020228;National Key R&D Program of China2020YFC2006100;Henan Province Key R&D and Promotion Special Science and Technology Project182102310179;Henan Province Medical Science and Technology Research Project2018020237, 2018020228