国家自然科学基金31670173;中国医学科学院医学与健康科技创新工程项目2016-I2M-1-019;云南省科技计划重大专项2017ZF020,2017ZF006National Natural Science Foundation of China31670173;CAMS Initiative for In-novative Medicine2016-I2M-1-019;Key Programs for Science and Technology Development of Yunnan Province of China2017ZF020, 2017ZF006