河南省基础与前沿技术研究计划项目142300410077;河南省医学科技攻关计划省部共建项目201601028;河南省卫生科技领军人才;河南省自然科学基金182300410384Science and Technology Bureau of Henan Province142300410077;Henan Prov-ince Health Department and National Health and Family Planning Commission of the People′s Republic of China Co-sponsored Project201601028;Henan Health Science and Technology Leading Talent Plan;Natural Science Foundation of Henan Province of China182300410384