国家自然科学基金81102227,81300124;深圳市科技计划项目JCYJ20140416141331464,JCYJ20140416141331478,JCYJ20150403100317055;深圳市卫生计生系统科研项目201401053,201402042,201501032Fund program:National Natural Science Foundation of China81102227,81300124;Science and Technology Project of ShenzhenJCYJ20140416141331464, JCYJ20140416141331478, JCYJ20150403100317055;Scientific Research Project of Health and Family Planning Commission of Shenzhen Municipality201401053,201402042,201501032