Emerging cellular-based therapies in carbon monoxide poisoning
万方数据知识服务平台
应用市场
我的应用
会员HOT
万方期刊
×

点击收藏,不怕下次找不到~

@万方数据
会员HOT

期刊专题

10.3760/cma.j.issn.0254-1424.2022.07.104

Emerging cellular-based therapies in carbon monoxide poisoning

引用
Carbon monoxide (CO) is an odorless and colorless gas with multiple sources that include engine exhaust, faulty furnaces, and other sources of incomplete combustion of carbon compounds such as house fires. The most serious complications for survivors of consequential CO exposure are persistent neurological sequelae occurring in up to 50% of patients. CO inhibits mitochondrial respiration by speci-fically binding to the heme a3 in the active site of CIV-like hydrogen sulfide, cyanide, and phosphides. Although hyperbaric oxygen remains the cornerstone for treatment, it has variable efficacy requiring new approaches to treatment. There is a paucity of cellular-based therapies in the area of CO poisoning, and there have been recent advancements that include antioxidants and a mitochondrial substrate prodrug. The succinate prodrugs derived from chemical modification of succinate are endeavored to enhance delivery of succinate to cells, increasing uptake of succinate into the mitochondria, and providing metabolic support for cells. The therapeutic intervention of succinate prodrugs is thus potentially applicable to patients with CO poisoning via metabolic support for fuel oxidation and possibly improving efficacy of HBO therapy.

44

2023-05-30(万方平台首次上网日期,不代表论文的发表时间)

共1页

670

相关文献
评论
暂无封面信息
查看本期封面目录

中华物理医学与康复杂志

0254-1424

42-1666/R

44

2022,44(7)

相关作者
相关机构

专业内容知识聚合服务平台

国家重点研发计划“现代服务业共性关键技术研发及应用示范”重点专项“4.8专业内容知识聚合服务技术研发与创新服务示范”

国家重点研发计划资助 课题编号:2019YFB1406304
National Key R&D Program of China Grant No. 2019YFB1406304

©天津万方数据有限公司 津ICP备20003920号-1

信息网络传播视听节目许可证 许可证号:0108284

网络出版服务许可证:(总)网出证(京)字096号

违法和不良信息举报电话:4000115888    举报邮箱:problem@wanfangdata.com.cn

举报专区:https://www.12377.cn/

客服邮箱:op@wanfangdata.com.cn