2015国家自然科学基金面上项目21475089;2015北京市教委科技创新平台项目PXM2015_014206_000053,PXM2015_014206_000072,PXM2015_014206_000051;Natural Science Foundation of ChinaGrant no. 21475089;Innovation Platform of Beijing MunicipalityPXM2015_014206_000053, PXM 2015_014206_000072, and PXM2015_014206_000051