Visuomotor task acquisition is reduced by priming paired associative stimulation in older adults

摘要：

BACKGROUND AND OBJECTIVES:Transcranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor task in young and older adults.METHODS:Fourteen young (20.4±0.6 years) and 13 older (69.0±1.6 years) adults participated in 3 experimental sessions during which training was preceded (primed) by PAS. Within each session, the interstimulus interval used for PAS was set at either the N20 latency plus 5 ms (PAS
LTP), the N20 latency minus 10 ms (PAS
LTD), or a constant 100 ms (PAS
Control).
RESULTS:After training, the level of motor skill was not different between PAS conditions in young subjects (all p-values > 0.2), but was reduced by both PAS
LTP (
P＝0.02) and PAS
LTD (
P＝0.0001) in older subjects.
CONCLUSION:Priming PAS was detrimental to skill acquisition in older adults, possibly suggesting a need for interventions that are optimized for use in elderly populations.

所属期刊栏目：42

在线出版日期：2023-05-30（万方平台首次上网日期，不代表论文的发表时间）

页数：共1页

页码：174