Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series

摘要：

BACKGROUND AND OBJECTIVES:Long-term paired associative stimulation (PAS) is a non-invasive combination of transcranial magnetic stimulation and peripheral nerve stimulation and leads to improved hand motor function in individuals with incomplete traumatic tetraplegia. Spinal cord injuries (SCIs) can also be induced by neurological diseases. We tested a similar long-term PAS approach in patients with non-traumatic neurological SCI.METHODS:In this case series, five patients with non-traumatic tetraplegia received PAS to the weaker upper limb 3 to 5 times per week for 6 weeks. Patients were evaluated by manual muscle testing (MMT) before and immediately after the therapy and at the 1- and 6-month follow-ups. Patients were also evaluated for spasticity, hand mechanical and digital dynamometry, pinch test and Box and Block test.RESULTS:MMT values of all patients improved at all post-PAS evaluations. The mean±standard error MMT increase was 1.44±0.37 points (
P＝0.043) immediately after PAS, 1.57±0.4 points (
P＝0.043) at the 1-month follow-up and 1.71±0.47 points (
P＝0.043) at the 6-month follow-up. The pinch test, digital dynamometry and Box and Block test results also improved in all patients.
CONCLUSION:S Long-term PAS may be a safe and effective treatment for improving hand function in patients with non-traumatic tetraplegia.SIGNIFICANCE:This is the first report demonstrating the therapeutic potential of PAS for neurological SCI.

所属期刊栏目：42

在线出版日期：2023-05-30（万方平台首次上网日期，不代表论文的发表时间）

页数：共1页

页码：116