安徽省临床医学研究转化专项项目202204295107020060,202204295107020010,202204295107020013;马鞍山市科技计划项目YL-2021-5;Translational Special Project of Clinical Medicine of Anhui Province of China202204295107020060, 202204295107020010, 202204295107020013;Ma′anshan Technology Fund ProgramYL-2021-05