National Basic Research Program of China973 Program2014CB542101;National Natural Science Foundation of China81472212;Special Scientific Research Fund of Public Welfare Profession of National Health and Family Planning Commission of China201502014国家重点基础研究发展计划项目973计划2014CB542101;国家自然科学基金资助项目81472212;国家卫生和计划生育委员会公益性行业科研专项子项目201502014