National Natural Science Foundation of China81773135,81672319;Beijing Municipal Science and Technology Plan ProjectsZ161100000516237;Beijing Science and Technology Commission Capital Public Health ProgramZ15110000391547;PLA Medical and Health Research Fund project16BJZ10;Bio-Science Innovation Research Major Subject Z171100000417023国家自然科学基金项目81773135,81672319;北京市科技计划课题Z161100000516237;北京市科委首都市民健康项目Z15110000391547;军队保健专项16BJZ10;北京市科委重点课题Z171100000417023