国家自然科学基金81500533、81670612;国家重点研发计划2016YFC0901502;上海市重中之重临床重点学科2017ZZ02009;上海市卫生和计划生育委员会科研课题20164Y0159The National Natural Science Foundation of China81500533,81670612;The National Key Research and Development Program of China2016YFC0901502;Shanghai Top Priority Key Clinical Disciplines Construction Project2017ZZ02009;Shanghai Municipal Commission of Health and Family Planning20164Y0159