国家自然科学基金81170674、81470937、81641024;中国医学科学院医学与健康科技创新工程2016-12M-2-004;中国医学科学院协和学者基金 National Natural Science Fund81170674,81470937,81641024;Medical and Health Innovation Project of Chinese Academy of Medical Science2016-12M-2-004;Chinese Academy of Medical Science & Peking Union Medical College Scholar Fund