“十三五”国家科技重大专项2017ZX10202203;国家自然科学基金81670536;广东省自然科学基金2016A030310108;广东省科技计划2016A020215008National Major Scientific and Technological Special Project during the 13th Five-year Plan Period2017ZX10202203;National Natural Science Foundation of China81670536;Guangdong Natural Science Foundation2016A030310108;Guangdong Province Science and Technology Program2016A020215008