国家自然科学基金81601667、81372033、81671888、81471842;2017天津市医学会麻醉学分会“精准麻醉”科研基金TJMZJJ-2017-01;天津市应用基础与前沿技术研究计划13JCQNJC11400National Natural Science Foundation of China81601667,81372033,81671888,81471842;" Precision Anesthesia" Scientific Research Fund of 2017 Tianjin Medical Association Anesthesiology BranchTJMZJJ-2017-01;Research Program of Tianjin Application Foundation and Frontier Technology13JCQNJC11400