北京市自然科学基金L212039;2021年北京市医管局扬帆计划XMLX202138;中国医学科学院中央级公益性科研院所基本科研业务费专项基金2021-JKCS-015;Beijing Municipal Natural Science FoundationL212039;Beijing Hospitals Authority Clinical Medicine Development of Special Funding SupportXMLX202138;Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences2021-JKCS-015