National Key R&D Program of China2016YFC1300700;Major Project of National Health Commission of ChinaGN-2016R0012;National Natural Science Fundation of China 81671137,81571126,8187093国家重点研发计划2016YFC1300700;国家卫健委重大项目GN-2016R0012;国家自然科学基金81671137,81571126,8187093