福建省自然科学基金面上项目2020J01958;福建省卫生健康中青年骨干人才培养项目2019-ZQN-56;国家自然科学基金81901209;福建省科技重大专项2017YZ0001-1;Fujian Provincial Natural Science Foundation2020J01958;Young and Middle-aged Backbone Key Research Project of the National Health and Family Planning Commission of Fujian Province2019-ZQN-56;National Natural Science Foundation of China81901209;Fujian Scientific and Technological Major Special Program2017YZ0001-1