国家自然科学基金资助项目81771366;湖南省卫生计生委科研计划课题A2017001;湖南省自然科学基金重点资助项目2017JJ2365;中华国际医学基金会资助项目CIMF-Z-2016-20-1801;National Natural Science Foundation of China81771366;Science Foundation of Health and Family Planning Commission of Hunan ProvinceA2017001;Hunan Provincial Natural Science Foundation2017JJ2365;China International Medical FoundationCIMF-Z-2016-20-1801