国家自然科学基金面上项目81171114,81571133;福建省自然科学基金资助项目2015J01392;福建省临床重点专科建设项目;福建省卫生系统中青年骨干人才培养项目2014-ZQN-ZD-18;福建省科技重大专项专题项目2017YZ0001-1General Program of National Natural Science Foundation of China81171114,81571133;Fujian Natural Science Foundation2015J01392;Fujian Key Clinical Specialty Discipline Construction Program;Fujian Provincial Medical Project for Middle-aged and Young Talents2014-ZQN-ZD-18;Fujian Scientific and Technological Major Special Program2017YZ0001-1