自然科学基金81470980,81600584;四川大学华西医院1.3.5工程项目ZY2016104;中央高校基础研究基金2017SCU11042;四川省卫生厅基金17PJ159Project supported by the National Natural Science Foundation of China81470980,81600584;1.3.5 project for disciplines of excellence,West China Hospital,Sichuan UniversityZY2016104;The fundamental Research Funds for the Central Universities2017SCU11042;The research fund of Sichuan Province Health Administration17PJ159