国家自然科学基金81773335、81803131;浙江省基础公益研究计划项目LGF18H110002;浙江省自然科学基金LQ16H290001、LY18H110001;National Natural Science Foundation of China81773335, 81803131;Zhejiang Basic Public Welfare Research ProjectLGF18H110002;Natural Science Foundation of Zhejiang Province of ChinaLQ16H290001, LY18H110001