国家自然科学基金81502739;国家973计划项目2013CB531600;江苏省自然科学基金BK20150068;江苏省十三五强卫工程项目ZDRCB2016010;中国医学科学院医学与健康科技创新工程项目2017-I2M-1-017National Natural Science Foundation of China81502739;National Basic Research Program 973 Program of China2013CB531600;Natural Science Foundation of Jiangsu Province of ChinaBK20150068;"Thirteen Five" Key Medical Talent's Project in Science and Education of Jiangsu ProvinceZDRCB2016010;CAMS Innovation Fund for Medical Sciences2017-I2M-1-017