国家自然科学基金81271758、81472887;卫生部科学研究基金——浙江省医药卫生重大科技计划项目WKJ2012-2-036;杭州市重大科技创新项目20122513A02National Natural Science Foundation of China81271758,81472887;Scientific Research Fund of the Ministry of Health-Major Science and Technology Projects of Zhejiang ProvinceWKJ2012-2-036;Major Science and Technology Innovation Projects of Hangzhou20122513A02