国家自然科学基金81271730;广东省科技厅课题2010B080702018;广州市医药卫生基金重点项目201102A212028Supported by grants from National Natural Science Foundation of China 81271730,Research Project of the Department of Science and Technology of Guangdong Province 2010B080702018 and Key Project of Guangzhou Health Foundation 201102A212028.